The study group of more than 17,000 Veterans included more than 11,000 patients with confirmed or likely cirrhosis, a liver disease that can result from hepatitis C, among other causes. The study team found surprisingly high response rates of around 87 percent in this group. The overall results were consistent with those from earlier clinical trials that led to FDA approval of the three new drug regimens in the study: sofosbuvir (SOF), ledipasvir/sofosbuvir (LDV/SOF) and paritaprevir/ ritonavir/ ombitasvir and dasabuvir (PrOD). The drugs, introduced in 2013 and 2014, have been credited with revolutionizing hepatitis C treatment, which means a cure is now in reach for the vast majority of patients infected with the virus. Previously, using earlier drug regimens, most patients could expect, at best, only a 50 percent chance of a cure. Our results demonstrate that LDV/SOF, PrOD and SOF regimens can achieve remarkably high SVR [sustained virologic response] rates in real-world clinical practice, VA researchers wrote. The new drug regimens examined in the study do not contain interferon, which has troublesome side effects such as fever, fatigue, and low blood counts. The newer drugs are considered far more tolerable than the older interferon-based antiviral regimens, although they are far more expensive. The researchers extracted anonymous data on all patients in VA care who received HCV antiviral treatments between January 2014 and June 2015 using the VA Corporate Data Warehouse, a national, continually updated repository of data from VAs computerized patient records.
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OMB, which issued the Directive jointly with the Archivist, may weigh in as well.” Congress has shown a willingness to take a strong hand in matters of email management, but typically in cases where there are political points to be scored. see this pageThe case of Hillary Clinton’s use of a personal email server for official business while serving as secretary of State dominated the 2016 presidential campaign for long stretches. On a lesser scale, email management practices played a part in a long-running scandal at the IRS, when thousands of emails from an employee accused of playing politics in tax-exemption determinations were mysteriously lost for a time before being recovered at a cost of millions of dollars. Brewer said that while such episodes are regrettable, they can serve to focus senior leaders on records management issues. “You never want to have bad things happen, but they do become object lessons for the rest of government,” Brewer said. “Those kinds of things become great training tools for us.” On the tech side, automation is an important piece of making electronic records management happen. Agencies that abandon the print-to-file system might upgrade only by manually dragging and dropping copies of relevant emails into records folders — a tedious task that is apt to be neglected. “The more that you can make it so that the system takes care of those processes, the easier it will be for the employee to do the right thing,” said April Chen, senior project manager at information management vendor Iron Mountain. But technology cuts two ways. When the policy was first being drawn up in 2011, email management was a resource issue as well as a records issue.
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