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The stem cells remodeled the heart muscle (myocardium) similar to normal myocardium. Stem cells in the heart may also secrete growth factors conducive to forming heart muscle and keeping the muscle from dying. “These key findings suggested these cells would work for HLHS patients,” says Kaushal. While stem cells have been used to regenerate adult hearts, Kaushal says improvements have been marginal. His research suggests results may be better in pediatric hearts: “The heart is able to remodel better in a younger patient than an older patient, because the body is still growing, good things are going on, and things are not deteriorating.” Civin, a pediatric oncologist, says his very first patient as a pediatric intern-in-training years ago was an infant with HLHS. “I’ve seen how devastating HLHS can be for babies and their families. I’m thrilled with the launch of this first-in-children stem cell therapeutic trial, and look forward to the patient outcomes.” The Department of Surgery at the University of Maryland School of Medicine is providing funding for the clinical costs associated with this trial. “Dr. Kaushal’s research will give families with a devastating diagnosis hope for a better outcome for their child,” says Stephen T. Bartlett, MD, the Peter Angelos Distinguished Professor; Chair of the Department of Surgery at the University of Maryland School of Medicine; and Surgeon-in-Chief and Executive Vice President of the University of Maryland Medical System.

For the original version including any supplementary images or video, visit https://www.eurekalert.org/pub_releases/2016-12/uomm-fub122016.php

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